Our research team is involved in the development of new reagents for a transformation that would facilitate the synthesis of previously difficult-to-access organofluorine compounds. More specifically, our group focuses on the development of reagents that can be used for fluoromethylene, fluorocarbene, and fluoromethyl radical transfer applications. These are chemical transformations where one-fluorine-one-carbon synthons (:CHF, :CFX, ·CH2F, ·OCH2F) are transferred from the reagent to a target substrate. This is a synthetically useful approach to access certain classes of monofluorinated compounds, such as small fluorinated cycles or monofluoromethylated products.

 

Concept/Reagents

 

       

                         

 

Synthetic Methods

 

Appplication in Med. Chem.

F-Cyclopropyl group in drug molecules:

CH₂F- group in drug molecules: