Our research team is involved in the development of new reagents for a transformation that would facilitate the synthesis of previously difficult to access organofluorine compounds. More specifically, our group deals with the development of reagents that can be used for fluoromethylene, fluorocarbene and fluoromethyl radical transfer applications. These are chemical transformation where one-fluorine-one-carbon synthons (:CHF, :CFX, ·CH₂F, ·OCH₂F ) are transferred from the reagent to a target substrate. These is a synthetically very useful approach to access certain classes of monofluorinated compounds, for example, small fluorinated cycles or monofluoromethylated products.

 

Concept/Reagents

 

       

                         

 

Synthetic Methods

 

Appplication in Med. Chem.

F-Cyclopropyl group in drug molecules:

CH₂F- group in drug molecules: