Our research team is involved in the development of new reagents for transformations that facilitate the synthesis of previously difficult-to-access organofluorine compounds. More specifically, our group focuses on developing reagents that can be used for fluoromethylene, fluorocarbene, and fluoromethyl radical transfer applications. These chemical transformations involve the transfer of one-fluorine-one-carbon synthons (:CHF, :CFX, ·CH2F, ·OCH2F) from the reagent to a target substrate. This approach is synthetically useful for accessing certain classes of monofluorinated compounds, such as small fluorinated rings or monofluoromethylated products.

 

Concept/Reagents

 

       

                         

 

Synthetic Methods

 

Appplication in Med. Chem.

F-Cyclopropyl group in drug molecules:

CH₂F- group in drug molecules: