Our research team is involved in the development of new reagents for a transformation that would facilitate the synthesis of previously difficult to access organofluorine compounds. More specifically, our group deals with the development of reagents that can be used for fluoromethylene transfer applications. This is a chemical transformation where one-fluorine-one-carbon-one-hydrogen unit (CHF:) is transferred from the reagent to a target substrate. This is a synthetically very useful approach to access certain classes of monofluorinated compounds, for example, small fluorinated cycles.

Concept/Reagents

Synthetic Methods

Appplication in Med. Chem.

F-Cyclopropyl group in drug molecules:

case study on Cabozantinib